Which of the following are true regarding B cell
development?
i. B cell precursors rearrange VDJ genes in the bone marrow
ii. Immature B cells only have one chance to rearrange VDJ genes to
pass negative selection
iii. Immature B cells interact with follicular dendritic cells in
the bone marrow to induce maturation
iv. Mature B cells circulate between lymph, blood, and secondary
lymphoid tissues to find their specified antigen
i, iv |
|
i, ii, iii, iv |
|
i, iii |
|
i, ii, iv |
All the options are correct with respect to the B cell development
This diagram depicts the stages of B cell development
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