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What is the affect of fatigue (ionic imbalance vs. ATP deprivation) on muscle? draw a graph...

What is the affect of fatigue (ionic imbalance vs. ATP deprivation) on muscle? draw a graph charting actvity vs. condition.

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Muscle fatigue

Decline in muscle force generated over sustain period of activity

In ionic imbalance • Contraction of a muscle requires Ca ions to interact with troponin, exposing the actin binding site to myosin head. • outside the muscles Osmotically active molecules are lost through sweating • Difficult for the required Ca ions to be delivered to muscle fiber•

ATP

Pyruvate produced by glycolysis is converted into additional ATP molecules in the mitochondria via Krebs Cycle • Pyruvate made in the cytoplasm is normally fed into the mitochondria, where it coulde be burn to co2 • When mitochondria are damaged and poisoned, and do not work well, they will not be able to keep up with the inflow of pyruvate

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