I was assigned the gene LOC_Os05g38000
Based on the available information about the gene predict the phenotype if the CRISPR experiment generated the deletion mutant. (Hint: Each gene has an image on Oryzabase.)
Someone please help!
LOC_Os05g38000 = ROPGEF7
It codes for a RHO guanyl-nucleotide exchange factor 7.
Molecular function:
It stimulates the exchange of Guanine nucleotides associated with
Rho GTPase family. They allow the exchange of bound GDP to GTP.
i.e. they act antagonistic to GAPs
If we delete GEF's, the GTPase is
bound always with GDP resulting in its inactivation. Due to this,
the downstream signaling events that ultimately lead to cell
proliferation, nuclear transprot, and cytoskeletal organization are
not initiated.
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