Question

Differences between covalent catalysis and covalent modifation of enzymes?

Differences between covalent catalysis and covalent modifation of enzymes?

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Differences between covalent catalysis and covalent modifation of enzymes

Covalent catalysis of enzyme- Covalent modificationof enzymes
1.

Is one of the strategy that an enzyme will employ to catalyze a specific reaction.

It occurs when the substrate in an enzymatic reaction become temporarily covalently attached to the enzyme during the catalytic reaction.

1.Covalent modification is the addition of group to the enzyme by covalent bond or removal of group by cleaving the covalent bond.
2.The reason for catalytic activity is a number of peptidase and esterase enzymes reacts covalently in substitution reactions by a two step nucleophillic mechanism. 2.covalent modification includes phosphorylation and dephosphorylation,acetylation and deacetylation,methylation and demethylation.
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