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Differences between covalent catalysis and covalent modifation of enzymes
Covalent catalysis of enzyme- | Covalent modificationof enzymes |
1.
Is one of the strategy that an enzyme will employ to catalyze a specific reaction. It occurs when the substrate in an enzymatic reaction become temporarily covalently attached to the enzyme during the catalytic reaction. |
1.Covalent modification is the addition of group to the enzyme by covalent bond or removal of group by cleaving the covalent bond. |
2.The reason for catalytic activity is a number of peptidase and esterase enzymes reacts covalently in substitution reactions by a two step nucleophillic mechanism. | 2.covalent modification includes phosphorylation and dephosphorylation,acetylation and deacetylation,methylation and demethylation. |
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