You have a patient who has a very strange disorder. In this disorder, ADP sticks permanently to the myosin head. From your knowledge of excitation contraction coupling, describe how this patient will present. Defend your position.
the above figures explain walk along hypothesis. ADP is required to bind to actin filaments at active sites. the release of ADP is necessary to leave the actin filament so that ATP binds to myosin head and returns to low energy configuration. myosin head now cannot bind to actin.
so, ADP binding results in contraction of the muscle. whereas, ADP release and ATP binding result in relaxation.
the patient in the question is suffering from a disorder, where ADP is unable to release from myosin head. therefore, the muscles are in a contracted state. hence, the muscles in the patients would be in tightened or contracted position.
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