Question

Two related but distinct neurological disorders are Prader-Willi syndrome (PWS) and Angelman syndrome (AS). Children with PWS are obese, have weak muscle tone, and delayed development. Children with AS have severe speech impairment, developmental delay, intellectual disability, and problems with movement and balance. However, both disorders are due to the deletion of the same part of chromosome 15. Hypothesize as to how this is possible

Answer 1

Answer:- Prader-Willi Syndrome and Angelman Syndrome both are due to deletion of the same part of chromosome 15. But these neurological disorders are distinct because:

PWS is caused due to deletion of some region of father's chromosome 15 or if the person has two copies of chromosome 15 from their mother and none from their father whereas in Angelman Syndrome (AS) there is deletion of some region of chromosome 15 from mother's or if person have two copies of chromosome 15 from their father and none from mother. So that the symptoms of these disorders are different.