Question

What is the differences and similarities between N-link and O-link glycocylation. Explain

Answer 1

Similarities-process for start in endoplasmic reticulum . After processing in endoplasmic reticulum, O-linked glycosylation occur in Golgi bodies.

Both are required for cell cell interaction and adhesion.

Difference- N-linked glycosylation start co-translationally in endoplasmic reticulum while O-linked glycosylation occur post-translationally in Golgi bodies.

N-linked glycosylation occur on asparagine residue while O-linked glycosylation occur on side chain hydroxyl oxygen of either serine or threonine.