Tumor rejection is primarily mediated by T lymphocytes, although antibodies can also be involved and cause Antibody Dependent Cellular Cytotoxicity (ADCC) or Compliment Dependent Cytotoxicity (CDC). Antibodies cause a anti-tumor activity by interfering with growth controlling mechanisms.
CD8+ and CD4+ lymphocytes play roles in cell mediated anti-tumor responses. CD4+ cells produce lymphokines that expand cytolytic T cells and activate macrophages and natural killer cells with anti-tumor activity. Tumor destruction is primarily mediated by Th1 type response, involving CTL and lymphokines and it may be inhibited by Th2 type lymphokines.
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