Question

Where in the world might basophils play a more prominent role in protective immunity than in other parts of the world?

Answer 1

ans)

1. Basophils were first described by Paul Ehrlich in 1989, who named them after their avid staining with basophilic dyes.

2. Basophils make up <1% of the peripheral blood leukocytes in mice and human. In these species basophils can be identified by their high surface expression of FcRI, immunoglobin E (Ig E), CD49b , and IL-3R

3. They can also be functionally identified by their rapid production of cytokines such as IL-4 and IL-13, and release histamine. Under homeostatic conditions, mature basophils can be found circulating in the peripheral blood as well as highly vascularized organs such as the liver, spleen, and bone marrow

4. Role of basophils as initiors and regulators of the adaptive immune response.

5. It play important role in allergic inflammation, protective respons against parasitic infection and immune regulation