Question

what are the roles of hemagglutinin and neuraminidase in the replication cycle of influenza viruses and in the origin of new influenza viruses?

Answer 1

Neuraminidase is the enzyme that would be cleaving the sialic groups present in the glycoproteins, as the influenza virus would be replicating it would be attaching to the surface with the help of hemaggluttin, which is a molecule that is found on the virus surface. This would be binding to the groups of sialic acid. This neuraminidase enzyme would be enabling the virus so that it would get released from the host.

As an important part of influenza replication, the virus gets released after budding. The vision contains hemaglutinin on its surface and this helps the vitriol for infection. The terminal neuraminidase acid would be cleaved from the glycine structures present on the infected cell surface. As a result, there would be a release of the progeny viruses spreading to the uninflected surfaces. Also, neuraminidase would be preventing virus aggregation.