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Neurofibromatosis is an autosomal dominant disease. The frequency of the recessive allele is 0.98. In population...

Neurofibromatosis is an autosomal dominant disease. The frequency of the recessive allele is 0.98. In population of 2250 how many individuals would you expect to not have the disease?

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Answer #1

If we consider p as frequency of dominant allele and q as frequency of receccive allele. Then it has given that q=0.98.

According to hardy Weinberg equilibrium, p+q=1 ,so p=1-0.98 =0.02

We have p2+2pq+q2=1 where p2= frequency of homozygous dominant individuals, q2=frequency of homozygous recessive individuals ,2pq=frequency of heterozygous individuals. Since it is autosomal dominant disorder, homozygous recessive and heterozygous individuals will be affected.and homozygous recessive individuals will be unaffected.

Here frequency of unaffected homozygous recessive individuals =q2=0.982=0.9604.

So number of unaffected individuals = 0.9604×2250 =2160.9 that is approximately 2161 individuals.

If the factors affecting hardy Weinberg equilibrium are not present.practically human populations don't meet its conditions and so the answer will be incorrect.

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