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Trinucleotide repeat expansion diseases, such as fragile X syndrome, display what type of inheritance pattern? Select...

Trinucleotide repeat expansion diseases, such as fragile X syndrome, display what type of inheritance pattern?

Select one: a. Regression b. Anticipation c. Nonvariable expressivity d. Phenotypic heterogenicity

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Answer #1

Option b. Anticipation.

In anticipation, the severity of a genetic disease increases, as it is transferred to the next generation. Trinucleotide repeat expansion diseases are characterized by presence of repeat sequences of three nucleotides in the genome. These repeat sequences can result in errors during DNA replication, mainly through replication slippage, as a result of which, increase in the number of repetitions of the sequences can occur, thus, increasing the occurrence of mutations in the next generation.

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