Question

Compare the active sites of the following enzymes : Cysteine Proteinase (SARS Coronavirus Main Proteinase) and Serine Proteinase (Chymotrypsin).

Answer 1

Cysteine proteases contain a Cys–His–Asn set of three at the dynamic site. A histidine buildup, presents in the dynamic site go about as proton giver and improve the nucleophilicity of the cysteine buildup.

The set of three is situated in the dynamic site of the protein, where catalysis happens, and is safeguarded in all superfamilies of serine protease compounds. The group of three is an organized structure comprising of three amino acids: His 57, Ser 195 (henceforth the name "serine protease") and Asp 102.