______ activates ppsinogen into pepsin and ___ activates trypsinogen into trypsin
a. amylase; enteropeptidase
b. nteropeptidase; HCl
c. lipase; pepsin
d. HCl; enteropeptidase
e. HCl ; amylase
Pepsinogen is a digestive enzyme secreted by the gastric chief cells. Pepsinogen is produced as a pro-enzyme. Hydrochloric acid (HCl) is secreted by parietal cells of the stomach as gastric acid in the gastric lumen. HCl activates pepsinogen to form the active enzyme pepsin. The acidic environment created by HCl is required for proper functioning of pepsin enzyme. Pepsinogen has additional 44 amino acids in its primary structure.
The inactive form of Trypsin is Trypsinogen. Trypsinogen is secreted by pancreas in pancreatic juice. An enteropeptidase located in brush border membranes of enterocytes in the duodenum converts Trypsinogen to Trypsin. Once Trypsin is formed, it cleaves more Trypsinogen to form Trypsin by auto activation.
Right choice is d. HCl, enteropeptidase
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