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GWAS are used to determine if a mutation or gene may be a risk factor for...

GWAS are used to determine if a mutation or gene may be a risk factor for disease. Which of the following statements regarding GWAS is CORRECT?

The lower the frequency of a SNP in the population, the more likely it will be associated with the disease.

GWAS compare the expression of many genes among healthy and sick individuals.

The higher the frequency of a SNP in the population, the more likely it will be associated with the disease.

GWAS identify differences in the frequency of SNPs among healthy and sick people.

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Answer #1

The genome-wide association study is a study of a genome-wide set of variants. the DNA of participants with various phenotype for a given trait are compared and the small nucleotide polymorphism is checked in them. It proceeds via phenotype first approach and SNP arrays are studied. If one type of variant is more frequent in people with a particular disease then this is thought to be associated with the disease.

So GWAS identifies the differences in the frequency of the SNPs among healthy and sick people.(option 4)

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