Question

Receptors coupled to Protein G DO NOT: A Stimulate the production of secondary messengers B Bind...

Receptors coupled to Protein G DO NOT:
A Stimulate the production of secondary messengers B Bind GTP
C Activate scramblase
D They are heterotrimeric
E They activate phospholipases
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Answer #1

The correct answer is D. This is because, heterotrimeric is the characterstic feature of G-Proteins not the receptors bound to it. Further all other mentioned features are activated when receptor bind to G-protein so the are correct. Here, we are asked to respond which is not the feature of recptors coupled to G-protein.

G-Protein is a trimeric unit made of alpha, beta and gamma subunit. GTP binds to alpha subunit when receptors bind to G-Protein. Phospholipase activation is one of the function of G-Protein coupled receptor. Also, activates secondary messanger like DAG and IP3. Activates phospholipid scramblase.

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