Question

A cell that is synthesizing insulin is lacking Signal Recognition Particle (SRP) receptors at the level of the rough endoplasmic reticulum. In your own words, describe the impact, if any, on the synthesis and secretion (exocytosis) of insulin from the cell. Explain your answer.

Answer 1

Due to absence of SRP ,there will be accumulation of proteins in cytosol of the cell.SRP absence  have little effect on cell growth,led to induction of a heat shock response which serves atleast in part to increase the capacity of cells to degrade IMPs that are mislocalised due to SRP defeciency.In general SRP act as an important intermediary in the transport of proteins into secretory pathway in cells therefore its absence effect secretion badly .Effect on mytosis is that protein accumulation occurs so the proteins from cell are released from a cell to extracelllular matrix.