Question

A Protein misfolding can be triggered by:

A. cleavage of a portion of secondary structure

B. Conversion of α-helix to β-strands

C. Alteration of tertiary structure

D. Change in pH

Either of the listed causes can cause misfolding.

Answer 1

Ans) Either of the listed causes can cause misfolding

Explaination: unfolding of protein is the process in which secondary and tertiary structure of protein disrupts and affect its biological function but primary structure of protein retain.

Cleavage of a portion of secondary structure disrupts secondary structure of protein ie, unfolding.

Conversion of alpha helix to beta strands alter the configuration of protein and disrupts its folding and biological function leading to unfolding.

Alternation of tertiary structure also leads to change in tertiary structure of protein that leads to unfolding.

Change in pH causes denaturation of protein ie, unfolding or disruption of tertiary and secondary structure.

So either of the listed causes can cause misfolding.