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what enzymatic model is able to explain the role of allosteric modulators

what enzymatic model is able to explain the role of allosteric modulators

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Answere : Induced-fit model is able to explain the role of allosteric modulators. Induced-fit model proposes that active site forms as the enzyme and substrate interact. The enzyme is seen as 'flexible' and can mould itself around the substrate. The enzyme does have a general shape, but it undergo conformational change in the presence of the substrate it is specific to.

Allosteric modulator is an enzyme that binds to the regulatory component of an enzyme, causing a conformation change in the catalytic subunit in order to increase or decrease the the activity of an enzyme. Allosteric activators will increase the activity of an enzyme while allosteric inhibitors will decrease the activity of an enzyme.

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