Question

How does histone acetylation affect transcription (positively or negatively)? What enzymes acetylate histones and what enzymes deacetylate?

Answer 1

How does histone acetylation affect transcription (positively or negatively)?

The answer is Positively becaue acetylation removes the positive charge on the histones by adding acetyl groups it leads to decreases the interaction between the histones and DNA which results more relaxed DNA. This relaxed DNA increases the levels of gene transcription.

What enzymes acetylate histones and what enzymes deacetylate?

These acetylation and deaceltyation reactions are catalysed by histone acetyltransferase (HAT) and histone deacetylase (HDAC) respectively.