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If you are given a monoclonal antibody and polyclonal antibody against a given protein, which do...

If you are given a monoclonal antibody and polyclonal antibody against a given protein, which do you think is mre likely to have clocking activity (to inhibit the function of the given protein)?

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Answer #1

Answer: Polyclonal antibody

Explanation: As we know that the polyclonal antibody can pair with different/ multiple types of epitopes at the same time. For this reaseo if i add this polyclonal antibody and there is presence of variation of different antigen outside so there is probability that the polyclonal antibody is going to stick to one or two different types of antigen inside. As they have huge affinity towards the antigen that is the advantage of polyclonal over monoclonal antibody.

As the protein shows the variation(in epitope) due to some changes( denaturation, change in structural conformation by variation in pH or by any mean) so polyclonal antibody is found to have more clocking activity over the monoclnal antibody.

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