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What is more likely to have a detrimental effect on the phenotype: a 1 base pair...

What is more likely to have a detrimental effect on the phenotype: a 1 base pair deletion at the very end of the coding sequence of a gene, or a 9 base pair deletion from the middle of the gene? Why? Would the outcome be different if the deletions happened within the gene’s intron? Why?

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Answer #1

Out of the two cases given, the one with more detrimental effect is the one where " 1 base is deleted at the end of the coding sequence "because the end of chain contain sequence required for the termination of protein translation.When the end base is deleted, the protein chain termination will not stop and protein structure and function will get change . Hence, phenotype will also alter.

On the other hand, deletion of 9 bases in the middle of gene, will remove three amino acid from the chain but protein chain be will be terminated correctly and will have least effect.  

If this deletion occur in the gene intron , then there will be no effect because intron contain non coding sequence, that are not a part of protein chain.

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