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Which types of proteins are best suited for 3D structural determination by X-ray crystallography? Which are...

Which types of proteins are best suited for 3D structural determination by X-ray crystallography? Which are worst suited?

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The proteins that are rigid and form nice ordered crystals are the best suited for 3D structural determination by X-ray crystallography because crystallography relies on having many many molecules aligned in a similar orientation like repeated pattern in wallpaper. Flexible proteins are worst suited because flexible portion of the protein will be invisible in crystallographic electron density maps because their electron density will be smeared over a large space.

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