Question

Describe the effect of glucagon on liver pyruvate kinase and how this affects glycolysis.

Describe the effect of glucagon on liver pyruvate kinase and how this affects glycolysis.

Science   Biology   
0 0
Add a commentTranscribed image text
Next >

Homework Answers

Answer #1

Glucagon is a hormone released from α cells of pancreas. It helps in increasing glucose and fatty acids concentration in blood. During low glucose concentration, glucagon increases phosphorylation of pyruvate kinase, phosphofructokinase and fructose-1, 6-bisphosphatase via cyclic AMP (cAMP) and its dependent proteins.

This results in inactivity of pyruvate kinase and decreased recycling of phosphoenolpyruvate which result in decreased glycolysis and increased glucose synthesis.

0 0
Know the answer?
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Log In

Sign Up

Not the answer you're looking for?
Ask your own homework help question
Similar Questions
Although it is not the primary flux-control point for glycolysis, pyruvate kinase is subject to allosteric...
Although it is not the primary flux-control point for glycolysis, pyruvate kinase is subject to allosteric regulation. What is the metabolic importance of regulating flux through the pyruvate kinase reaction? As part of you answer, write a balanced equations for 1) the conversion of glucose to pyruvate and back to glucose & 2) the conversion of glucose to phosphoenolpyruvate and back to glucose.
*please explain* Glucagon does not a) decrease glycogen synthesis in the liver. b) decrease glycolysis in...
*please explain* Glucagon does not a) decrease glycogen synthesis in the liver. b) decrease glycolysis in the liver. c)increase TAG breakdown in adipose tissue. d)decrease glycogen synthesis in muscle.
The following question refers to regulated enzymes in glycolysis. Here is a summary of these enzymes....
The following question refers to regulated enzymes in glycolysis. Here is a summary of these enzymes. glycolysis reaction #1 is catalyzed by hexokinase glycolysis reaction #3 is catalyzed by phosphofructokinase (PFK) glycolysis reaction #10 is catalyzed by pyruvate kinase Which of the following statements about glycolysis regulation in liver cells is/are TRUE? All of the statements are true Liver hexokinase has a very low Km compared to muscle hexokinase Liver pyruvate kinase is activated allosterically by a glycolysis intermediate. Liver...
Briefly describe what the following hormones do to glycolysis or gluconeogenesis: A Insulin B Glucagon
Briefly describe what the following hormones do to glycolysis or gluconeogenesis: A Insulin B Glucagon
What is the effect of increased glucagon levels on the amount of glycogen stored in the...
What is the effect of increased glucagon levels on the amount of glycogen stored in the liver? Increased glucagon will decrease the amount of glycogen stored in the liver. Increased glucagon will increase the amount of glycogen stored in the liver. Increased glucagon will not change the amount of glycogen stored in the liver.
Pyruvate kinase M2 (PKM2) is expressed in most cancer cells. It has a reduced catalytic activity...
Pyruvate kinase M2 (PKM2) is expressed in most cancer cells. It has a reduced catalytic activity relative to PKM1, which is expressed in quiescent cells. The significance of PKM2 expression in cancer cells is that PKM2 enhances the conversion of pyruvate to lactate and the regeneration of NAD+ needed for glycolysis to continue. True or False
What might be the effect on liver function of a mutation in a gene that encodes...
What might be the effect on liver function of a mutation in a gene that encodes a cAMP phosphodiesterase? Of a mutation in a gene encoding a glucagon receptor? Of a mutation in a gene encoding phosphorylase kinase? Of a mutation that altered the active site of the GTPase of a G subunit? (Assume in all cases that the mutation causes a loss of function of the gene product.)
If electrons are received from glycolysis and the pyruvate dehydrogenase, how many molecules of oxygen can...
If electrons are received from glycolysis and the pyruvate dehydrogenase, how many molecules of oxygen can be reduced by one glucose molecule?
In metabolizing fructose, liver converts fructose directly to fructose-6-phosphate for glycolysis.                   A. True        &n
In metabolizing fructose, liver converts fructose directly to fructose-6-phosphate for glycolysis.                   A. True                        B. False Carbons are incorporated into the glyoxylate cycle from?                   A. Bicarbonate                        B. Acetyl CoA            C. Malate At normal situation, when blood glucose reaches 100mg/dl, which of the following events is inhibited in the liver?                   A. Gluconeogenesis    B. Lipogenesis                        C. Glycogen synthesis           Which of the following reaction fixes carbon?                   A. From succinate to fumarate                       B. From pyruvate to...
When there is a high level of Insulin in the blood stream, glucagon makes (how does...
When there is a high level of Insulin in the blood stream, glucagon makes (how does is he make?) the liver convert glycogen to glucose (the proccess is called glycogenolysis?), which increases the level of insulin in the bloodstream when insulin level are high in the bloodstream, glucagon makes (again, how?) the liver convert glucose to glycogen and store it (in glucogenesis?) so I got to this conclusion.. am I getting it right? could you explain what glycolgenolysis and glucogenesis...
ADVERTISEMENT
Need Online Homework Help?

Get Answers For Free
Most questions answered within 1 hours.

Ask a Question
ADVERTISEMENT