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9. Explain the main events in S phase: S-Cdk, ORC. What is the key process being...

9. Explain the main events in S phase: S-Cdk, ORC. What is the key process being controlled here?

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Answer #1

The main events in S phase:

S-CDK phosphorylates Cdc6 (degrades Cdc6)

Geminin accumulates and inhibits Cdt1

S-CDK phosphorylates ORC

S-CDK is responsible to stimulate the synthesis of DNA and chromosomal proteins (histones)

Active S-CDK phosphorylates Cdc6 and ORC for chromosome replication.

The key processes being controlled in S phase:

Replication of DNA

Synthesis of proteins associated with DNA

Active S Cyclin-CDK allows a single round of DNA synthesis per cell cycle

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