Question

Describe a hypothetical lipid or polymer-based carrier for enhanced delivery of antisense oligonucleotides.

Answer 1

a variety of non viral methods for the delivery of antisence oligonucletides into cells have been given below

(a)these include cationic liquid complers.

(b)polypeptides

(c)surfactants

(d)liposomes and other reagents one promising type of delivery agents starburst polyamidaomine dendrimers are spherical highly or dered.

the dendrimers oligonucleotides complex remained associated during the process.

so,multiply pranched polymers with positivelty charged primary amino groups on their surfaces at physiological ph.

these surface amino groups provide useful moieties .for the functional modificatio dendrimers .it will allow covalent coupling reaction.