A virgin Drosophila female whose thorax bristles are very short is mated with a males having normal (long) bristles. The F1 progeny are 1/3 short-bristle females, 1/3 long bristle females, and 1/3 long bristle males. A cross of the F1 long bristle females with their brothers gives only long bristle F2 progeny. A cross of short bristle females with their brothers gave 1/3 long bristle females, 1/3 short bristle females, and 1/3 long bristle males. A) Explain what is going on genetically and B) why short bristled females can not be homozygous.
A. Recessive cell lethal mutation is the condition, where homozygous recessive allele turns out to be lethal and eliminates the organism. Such a mutation can be attributed to P element mutagenesis in Drosophila.
B. In Drsosphila, P element codes for protein P transposase. These are common mutagenic agents in Drosophila. Wild type flies have express an inhibitor to the transposase activity of this protein. Since the disruption caused by P element to the genome is stopped, fertile progenies that are healthy can be born. However, in the absence of such an inhibitor, the P element gains access into the genome and to proliferate. in the process, the element disrupts many genes and kills the progeny. Hence, specifically a female Drosophila (homozygous recessive) may not be able to survive.
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