Question

• Describe the role of TAM [tumor associated macrophages] in comparison to regular macrophages

Answer 1

TAMs are found in the microenvironment of solid tumours which are mainly involved in cancer related inflammation. They have a very weak ability to present antigen unlike macrophages. They can enhance proliferation, invasion and metastasis of tumor cells; and by stimulating angiogenesis, inhibiting T-cell mediated anti tumor immune response promote progression of tumor.

Whereas

Macrophages are cells of the immune system that phagocytes and digests foreign particles, microbes, cancer cells. They have a vital role in imparting innate immunity and adaptive immunity. They are anti-inflammatory by nature and decrease immune reactions by release of cytokines.