Question

• what is heterotypical signaling and what cells may be involved. explain the role of the cells in cancer progression.

Answer 1

Heterotypic signalling is the type of signalling between two different type of cell used to encourage proliferation.Cells of dissimilar origin communicate in order to do the interactions through, small molecular signals, proteins, and peptides.

Earlier, it was supposed that cancer may occur due to the mutation in the gene only, whereas now a days it, has shown experimentally that heterotypic signalling may also involve in the cancer formation.

Research have shown that paracrine signalling, that is cell to cell interaction generate a signal that alter the behaviour of nearby cells. Paracrine signalling between different type of cell types within the carcinomas, such as endothelial cells and inflammatory cells that lead to the formation of carcinoma.