Question

a biomaterial contains a procatcinogenic component that leaches out of the material. Enzyme A is required to metabolize procarcinogen to carcinogen. mutagenesis does not occur in cells surrounding the biomaterial but does occur in the liver in hepatocytes. hepatocytes secrete enzyme A.

1) what type of malignant transformation would be encountered?

a. chemical carcinogenesis

b. foreign body carcinogenesis

c. none of the above

2) what major histocomparibility complex molecule would bind to the mutated cell antigens?

a. MHC class 1

b. MHC class 2

c. none of the above

Answer 1

Question 1) option c none of above

Here actual foreign material is procarconogenic actually not harmful. But in side the body it is metabolize by the liver in order to get excrete it from the body. But actually converting it in to toxic form .this type of transformation is known as biotransformation.

Question 2) option A, MHC I molecules

mutated cellular antigens are processed by cytosolic pathway and expressed by MHC I molecules.

While extracellular antigens uptake by endocytosis and after processing expressed with MHC II molecule