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Write the structural formula for the dinucleotide CpT and calculate its net charge at physiological pH...

Write the structural formula for the dinucleotide CpT and calculate its net charge at physiological pH (7.4).

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Answer #1

The pKa of the phosphate group of phosphodiester bond is near to 0, therefore at pH, 7.35, it will be negatively charged. Hence the CpT will be ( -1) negatively charged as shown in the figure at physiological condition.

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