Question

Which of the following changes is more likely to further confine a membrane protein within a corral established by the cortical cytoskeletal network?

		Increased temperature
		Protease cleavage of the extracellular domain of the protein
		Binding to an extracellular ligand
		Protease cleavage of the cytosolic domain of the protein
		Binding of the protein to other transmembrane proteins

Answer 1

Answer Option 5.Binding of protein to other transmembrane protein.

A protein called spectrin is present in the cortex.Spectrin proteins and actin microfilaments are attached to transmembrane protein.This will further confine a membrane protein within a corral established by the cortical cytoskeletal network.

Option 1 is wrong .Increased temperature results in increased fluidity.So increased temperature will not further confine a membrane protein.

Option 2 and 4 is incorrect .Proteolytic cleavage results in the release of significant portions of their extracellular and intracellular domains.

Option 3 is also incorrect ,binding to an extracellular ligand enhances signaling.It will not further confine a membrane protein within a cytoskeletal corral.