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Compare and contrast the Bcl2 family proteins.

Compare and contrast the Bcl2 family proteins.

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The bcl2 family proteins are those proteins that can pevents apoptosis as they prevents functioning of apoptoptic proteins or they can also promote apoptopsis by helping in release of cytochrome c from mitochondrial membrane.They have a BCL2 domain or homology domain which are BH1 ,BH2 ,BH3 and BH4.

On basis of these domains the bcl2 family proteins can be divided in to two as BH domain is essential for normal functioning. Which are those which have several BH domain eg Bax and others have only one BH3 domain which is BAD and these play main role in causing apoptosis.

Hence the BH3 domain is the domain present in all types of Bcl2 family protein as this domain is necessary for diamerizsation and other important functions.

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