Question

Uniden’s condition is an X-linked recessive trait in the Redialer population. The trait allele F has a frequency of 0.005 in this population; that is. the frequency is the same in the male and female populations. Individuals with this trait have a strong desire to use land-line phones. Note, the trait gene is in Hardy Weinberg Equilibrium (HWE) for the female Redialer population.

An man with the trait and an woman without the trait have a son. What is the probability that the son has Uniden's condition?

(Hint: Use the HWE equation to determine the most likely genotype in the woman).

A. 1E-05.

B. 0.5

C. 0.0

D. 0.25

E. 0.005.

Answer 1

Unidens condition is a X linked recessive trait. A man with the trait and s woman without the trait have a son.

The frequency of F allele is 0.005. Therefore, the frequency of f allele is 0.995. The frequency of individuals with different genotypes are as follows,

FF = (0.005)*0.005) = 0.000025

F f = 2(0.005)(0.995) = 0.00995

f f = (0.995)(0.995) = 0.99

Man with the trait and woman without the trait have the disease. The probability of having an affected son is 0.25.