Question

In the wobble position, inosine can bind to adenine, cytosine, and uracil, but not to guanine. Why not?

A. Inosine and guanine have the wrong arrangement of partial charges to form noncovalent bonds.
B. Inosine is created by chemical modification of guanine.
C. Inosine is created by chemical modification of adenine.
D. Guanine is a purine, and therefore too large to bind to inosine.

Answer 1

In the Wobble position, inosine can bind to adenine, cytosine and uracil but not to guanine because inosine is derived from the adenine by the process deamination of adenosine. Inosine have the similar structure of guanine( like 6' carbonyl and 1' amine for making H-bond ) but only differs from guanine by loss of 2'amine gruop and have electrostatically similar to guanine.Thus inosine is prefer to bond with cytosine. Inosine have two sites for making H-bond in a configuration that capable to bind with adenine and uracil also..

So, the answer is - - A. Inosine and guanine have the wrong arrangement of partial charges to form noncovalent bonds.