Question

A. Who was Grady Stiles? What was the likely genetic defect? Describe how development is impacted, and the inheritance pattern.

B. Have you heard of Hemingway cats? What’s up with their feet? What signaling pathway is perturbed? When this occurs in humans what are some other developmental defects associated with this condition?

C. Describe heart development, starting at neurula stage. Relate genetics associated with congenital heart defects to this process

Answer 1

A. Mr. Grady Stiles was a freak show performer who belonged to America. He was suffering from a genetic condition termed as ectrodactyly. In this condition, the libs of a person are fused together and thus forming deformity. His hands and feet looked like a lobster dan thus he was named as theLobster boy used as his stage name.

Stiles was suffering from ectrodactyly and this made his locomotion difficult. He used to walk on all fours and this resulted in the deposition of body fat and even took to the wheelchair. He was frustrated with his condition and suffered from depression.

Ectrodactyly is a congenital disorder and gets inherited with reduced penetration and autosomal dominant, this being the common form of inheritance. Likewise, X linked forms and autosomal recessive are rare to find. Studies suggest that a duplication on 10q24 leads to ectrodactyly.