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What approaches overcame the challenge of repetitive sequences in the human genome project? a. use of...

What approaches overcame the challenge of repetitive sequences in the human genome project?

a.

use of libraries with large genomic DNA pieces in bacterial artificial chromosomes subdivided into small subclones  
b.

mapping and alignment of restriction sites for each assembled BAC clone with human genome physical map
c.

they removed the repetitive sequences by hybridization before sequencing
d.

A and B
e.

A, B, and C
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