Question

Cellular Dysfunction

-Decreased pH in cytosol below the normal range

-Decreased pH in mitochondria below the normal range

-Increase in Hydrolysis

-Inherited Autosomal Recessive Mutation of hydrolytic enzymes

-Increased activity of mitogen-activated protein kinase(s)

-Poor Ion transport

1. Identify and explain how the system of a single cell is supposed to function in a normal environment and is being affected by the items listed in your challenge. This means explaining how all aspects of the cell (inside and outside) may be impacted by these problems. The chain reaction of the system inside the cell.

a. Make sure to fully explain all of the items listed in the cellular dysfunction as well as all other related items in the system of a cell.

2. Identify and explain any causes that you believe may be associated with these cellular problems in one cell.

3. Explain how your team plans to fix the one cell with these problems using cell biology and bioscience applications, such as Gene Therapy, etc.

Answer 1

All these cellular dysfunctions causes a disease called lysosomal storage disease.

The subcellular organelle lysosomes are responsible for the physiologic turnover of cell constituents.

Lysosomes are subcellular organelles responsible for the physiologic turnover of cell constituents. They contain catabolic enzymes, which require a low pH environment in order to function optimally. Lysosomal storage disease belongs to heterogenous group of dozens of rare autosomal storage disorders characterized by the accumulation of undigested or partially digested macromolecules. This causes cellular dyfunction and clinical abnormalities.

Enzyme replacement therapy is the potential therapy which now these days is using for the treatment of lysosomal storage disorders.