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If doxazosin cannot form a glucuronide conjugate, then what additional metabolism must oculcur before glucuronidation can...

If doxazosin cannot form a glucuronide conjugate, then what additional metabolism must oculcur before glucuronidation can proceed?
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Glucuronidation is the process of transfer of glucuronic acid component of uridine diphosphate glucuronic acid to a substrate by the enzyme glucuronyl transferase. Glucuronidation makes the substances more water soluble so that they can be easily eliminated from the body.

Glucuronidation is induced by substances which stimulate CYP1A2 and glucuronyl transferase enzymes like rifampicin, phenobarbitone, phenytoin and tobacco smoking. Therefore, if doxazosin cannot form a glucuronide conjgate, the above metabolism may favor glucuronidation.

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