Question

In a particular cell you cannot detect any protein product, even though there many mRNA copies...

In a particular cell you cannot detect any protein product, even though there many mRNA copies of this gene present in the cytoplasm. Which part of the gene is likely mutated?

A. Ribosome binding site of the 5' UTR of the mRNA

B. Promoter sequence of the DNA

C. microRNA cognition site of the 3' UTR of the mRNA

D. Poly-adenylation signal of the 3'UTR of the mRNA

E. enhancer site of the DNA

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Answer #1

A. Ribosome binding site of the 5'UTR of mRNA may be mutated in this case. This is the untranslated region on mRNA and contains the ribosome binding site. The translation of mRNA begins with the assembly of initiation factors (IF1, IF2 and IF3 ) to the wmall subunit of ribosome. Then this assembly and methionine-carrying tRNA bind to mRNA and initiate the translation process.

Thus, any defect in 5'UTR may stop tge complete translation process. So this may be the reason behimd the above-mentioned problem.

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