Ed Yong is a science journalist who wrote a book on the Human Microbiome called “I Contain Multitudes”. The book
was fascinating because it describes the good role our resident bacteria have on our bodies. In particular, he
mentioned one study that looked at the effect of good bacteria on the health of our intestinal system and how a poor
diet can change the bacterial communities (microbiome) inside the gut. The study wanted to prove that both a poor
diet and bad gut bacteria lead to malnourishment. Researchers collected gut bacteria from healthy children living in
the US and gut bacteria from malnourished children living in the African country of Malawi, where there is a crisis with
hunger and child malnourishment. They transferred both groups of gut bacteria into germ-free mice (mice with no
bacteria in their gut) and weighed the mice 2 weeks after the transfer. The experimental setup looked like this:
1. Group A received no gut bacteria.
2. Group B received bacteria from healthy children.
3. Group C received gut bacteria from malnourished children
ALL 3 GROUPS WERE FED A REGULAR DIET AND WEIGHED AFTER 2 WEEKS.
They found that mice that had bacteria from malnourished children lost weight even when given a good diet. Mice with
bacteria from healthy children did not lose weight. The group went on to identify specific bacteria from the gut of
healthy children so they could try to transfer those bacteria into the mice to see if the mice could revert to gaining
weight.
Based on the scenario above, describe an appropriate
“if/then”
statement for this situation.
What was the dependent variable (i.e. what were the scientists measuring in the mice?) in the main experiment?
Which group of mice is considered the negative control group?
What could be a next step for their investigation?
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