Question

The evolution of PL^pro and the p53-IRF7-IFNb pathways can be considered an example of co-evolution

True or False

Answer 1

Co-evolution is a phhenomenon where 2 traits or species or genes have reciprocating effect on each other's evolution and is selected by natural selection.

p53 generally is known to have antiviral properties by the type-I IFN response.

PLpro has the ability to block the p53-IRF7-IFNb pathway by deubiquitinating and stabilising a p53 degradation stimulator (MDM2).

Therefore, p53 and can act against each other with reciprocating effects to be selected only by natural selection.

Thus the statement in the question: "The evolution of PLpro and the p53-IRF7-IFNb pathways can be considered an example of co-evolution" is true.