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how would an adipocyte's response to glucagon be affected by the inhibition of adenylyl cyclase?

how would an adipocyte's response to glucagon be affected by the inhibition of adenylyl cyclase?

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Ans. The pancreas release glucagon. activates hepatic gluconeogenesis .

Glucagon also appears to have a minor effect of enhancing lipolysis of triglyceride in adipose tissue, which could be viewed as an additional means of conserving blood glucose by providing fatty acid fuel to most cell.

High glucose decrease the level and function of Gi protein in A10 VSMC and arota . It decreases the level and activities of Gi protein and adenyl cyclase signalling induced by hyperglycemia may be one of the important mechanism contributing to the cardiovascular complications associated with diabetes.

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