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Which of the following statements about p53 are correct? [mark all correct answers] a.p53 is a...

Which of the following statements about p53 are correct?

[mark all correct answers]

a.p53 is a tumor suppressor gene

b.p53 is an oncogene

c.p53 has cytotoxic activity

d.p53 enhances the antiviral response

e.p53 is activated by MDM2

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Answer #1

a. p53 is a tumor suppressor gene

d. p53 enhances the antiviral response

c. p53 has cytotoxic activity

Explanation:

In general p53 is a tumor suppressor gene. When it is mutated, then it becomes an oncogene.

Wild-type p53 in different cell types has similarly been associated with either enhancement of or increased resistance to the cytotoxicity of many cancer therapeutic agents

The p53 stimulates the expression of MDM2; MDM2, in turn, inhibits p53 activity

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