Question

When cells are treated with drugs that deplymerize microtubules, the Golgi apparatus is fragmented into small...

When cells are treated with drugs that deplymerize microtubules, the Golgi apparatus is fragmented into small vesicles and dispersed throughout each cell. When such drugs are removed, cells typically recover and grow normally. does this mean that the Golgi apparatus has formed again from the vesicles? if so how do you suppose it might happen? if not what is your explanation?

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Answer #1

The Golgi apparatus is fragmented into small vesicles due to the depolarization of the microtubules as the juxtanuclear localization of the Golgi apparatus is disrupted. The fragments/ vesicles of Golgi are composed of stacked cisternae that are small and resembles the intact stacks of Golgi. When the drug causing the fragmentation is removed, the polymerization of the microtubules restarts and the fragments/vesicles of the Golgi apparatus translocate along with them, and the Golgi is reformed.

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