Question

Besides the existence of tumor-specific T cells and B cells, many studies have demonstrated that high numbers of tumor-infiltrating lymphocytes are associated with good clinical outcome. In addition, not only the density but also the organization of tumor-infiltrating immune cells has been shown to determine cancer patient survival. Indeed, more and more studies describe the development within the tumor microenvironment of this anatomic micro-structure, whose presence has a positive impact on tumor prognosis. What is it?

Answer 1

Presence of CD3 (cluster of differentiation) protein complex molecules over the tumor cells is detected by T cells and is studied for its development. It is one of key factor for the effectiveness of calling lymphocytes near the microenvironment of tumor are not able to penetrate in tumor may be due to being less in number but when these tumor infiltrating lymphocytes are taken and grown ex vivo and reinjected in high number has great chances to combat the tumor.