When is Fis(Inbreeding coefficient) significant?
The coefficient of inbreeding of an individual is the probability that two alleles at any locus in an individual are identical by descent from the common ancestor(s) of the two parents.
The coefficient of inbreeding is: The probability that two alleles at a given locus are identical by descent.
So, in terms of health, a COI less than 5% is definitely best. Above that, there are detrimental effects and risks, and the breeder needs to weigh these against whatever benefit is expected to gained. Inbreeding levels of 5-10% will have modest detrimental effects on the offspring
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