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What are all the possibilities of genotypes and phenotypes formed in the combination of alleles responsible...

What are all the possibilities of genotypes and phenotypes formed in the combination of alleles responsible for the production of factor VIII?

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Answer #1

Factor VII is a blood clotting protein or factor helps in blood coagulation also known as anti-hemophilic factor (AHF) which is encoded by F8 gene. Any defects in F8 gene results in reccessive X linked disease hemophilia A. If we Consider two alleles Xh and X, in which Xh represents allele for hemophilia A.

Then the possible genotypes are:

  • XX, XXh and XhXh are in women
  • XY and XhY are in men.

If we Consider the phenotypes the factor VIII is produced in every individual which contains at least one non-affected X chromosome.

Therefore the Normal phenotypes are:

  • XX and XXh in women
  • XY in men

If we Consider the phenotypes the factor VIII is produced in those individual which does not contains one non-affected X chromosome.

Therefore the Abnormal or diseased phenotypes are:

  • XhXh in women
  • XhY in men
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