Answer:
What is the clinical deficiency presented by hemophilic
people?
- Hemophilia is a mostly inherited genetic blood clotting
disorder. There are two types of Hemophilia - A and B
- Both Hemophilia A and B are X linked recessive heriditary
disorders.
- Hemophilia A is caused due to the defective or
deficient factor VIII
- Hemophilia B is caused due to deficiency of factor
IX. In some cases, factor IX may be present, but it is
non-functional.
What is the genetic cause of that
deficiency?
- Hemophilia A is caused due to a mutation in the gene that
encodes coagulation factor VIII.
- This gene is present on chromosome Xq28
- Hemophilia B is caused due to a mutation in the gene that
encodes coagulation factor IX.
- This gene is present on chromosome Xq27.1
- Since Hemophilia is X-linked disorder, therefore, it can be
passed down only from mother.