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Does coagulation involve a positive feedback mechanism or a negative feedback mechanism

Does coagulation involve a positive feedback mechanism or a negative feedback mechanism

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Answer #1

Coagulation is essential in arrestimg bleeding from an injured site of the body.Blood coagulation occurs in three steps as follows:

1.Formation of Prothrombin activator

2.Conversion of Prothrombin into Thrombin

3.Conversion of Fibrinogen into Fibrin by thrombin.

The ultimate aim is conversion of fribrinogen into fibrin.Thrombin along with conversion of fibrinogen into fibrin is also responsible for positive feedback activation.

A positive feedback activation mechanism causes the conversion of even Prothrombin to thrombin.

This greatly accelerates the process of blood clotting enabling blood clot to form as soon as possible.

The below given flowchart clearly shows the positive feedback mechanism in coagulation:

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